NOD SCID
모델명
NOD.Cg-Prkdcscid/NifdcSmoc
카탈로그
SM-019
모델 상태
Repository Live
유전자 요약
Official Symbol
Prkdc
모델 설명
The scid mutation has been transferred onto a diabetes-susceptible Non-Obese Diabetic (NOD) background. NOD-Scid mice do not develop diabetes, lack T and B cells, and are inherently immune deficient, making them good recipients for transplantation of human hematopoietic stem cells and human solid tumors.
검증 데이터
Fig1. Body weight growth curve of NOD SCID (n=168)
Fig 2. Detection of serum antibody subclasses in NOD SCID mice (8-week old, male).
Fig3. Complete deletion of T, B and NK cells of NOD SCID mice. Spleen and peripheral blood cells NOD SCID mice were collected to analyze their compositions of T, B and NK cells by FACS.
Fig4. Complete deletion of Monocytes, macrophages and DC cells of NOD SCID mice. Spleen and peripheral blood cells NOD SCID mice were collected to analyze their compositions of Monocytes, macrophages and DC cells by FACS.
Fig5. Pathological examination of various tissues in NOD SCID mice. Thymus was absent in NOD SCID mice, and no significant pathologic abnormalities were found in the other tissues examined (8-week old, A males, B females).
Fig6. Subcutaneous xenograft tumor growth in NOD SCID.
Fig7. Blood routine tests in NOD SCID.
Fig8. Blood biochemistry in NOD SCID.
Table 1. NOD SCID xenograft cell lines
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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