Csf2-KO

모델명

C57BL/6Smoc-Csf2em2Smoc

카탈로그

NM-KO-190532

모델 상태

Embryo cryopreservation

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유전자 요약

Official Symbol
Csf2

Synonyms

Csfgm， GMCSF， Gm-CSf， MGI-IGM

NCBI ID

12981

MGI ID

1339752

Ensembl ID

ENSMUSG00000018916

Pubmed

Csf2

Human Ortholog

CSF2

모델 설명

Exon 1-3 of Csf2 gene was deleted to generate Csf2 knockout mice.
신청분야：Growth Factors，NF-KB pathway，Allergy and Asthma，

Disease Connection

Systemic Lupus Erythematosus

Phenotype(s)

MGI:3586342
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Il3-KO(NM-KO-190498) mice.

Reference(s)

Enzler T, Gillessen S, Manis JP, Ferguson D, Fleming J, Alt FW, Mihm M, Dranoff G, Deficiencies of GM-CSF and interferon gamma link inflammation and cancer. J Exp Med. 2003 May 5;197(9):1213-9

Pulmonary Alveolar Proteinosis

Phenotype(s)

MGI:2652689

Reference(s)

Stanley E, Lieschke GJ, Grail D, Metcalf D, Hodgson G, Gall JA, Maher DW, Cebon J, Sinickas V, Dunn AR, Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology. Proc Natl Acad Sci U S A. 1994 Jun 7;91(12):5592-6

당신은 또한 좋아할 수 있습니다

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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