F9-KO(2)

모델명

C57BL/6Smoc-F9em3Smoc

카탈로그

NM-KO-200607

모델 상태

Embryo cryopreservation

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유전자 요약

Official Symbol
F9

Synonyms

Cf9; Cf-9; AW111646

NCBI ID

14071

MGI ID

88384

Ensembl ID

ENSMUSG00000031138

Pubmed

F9

Human Ortholog

F9

모델 설명

F9-KO(2) mice (Stock No.NM-KO-200607）carry a knockout allele derived from the targeted deletion of exon 1-8. While F9-KO mice (Stock No.NM-KO-18046) carrying the exon 8 deletion.
신청분야：Hemophilia B

Disease Connection

hemophilia B

Phenotype(s)

MGI:2175873

Reference(s)

Wang L, Zoppe M, Hackeng TM, Griffin JH, Lee KF, Verma IM, A factor IX-deficient mouse model for hemophilia B gene therapy. Proc Natl Acad Sci U S A. 1997 Oct 14;94(21):11563-6

검증 데이터

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Fig1. Detection of the blood coagulation index in F9-KO(2) mice.

(A) Activated partial thromboplastin time (APTT) assay showed that F9-KO(2) mice took significantly longer to clot than WT mice. 

(B) The results of fibrinogen(FIB) detection showed that there was no significant difference in FIB values between F9-KO(2) mice and WT mice.

당신은 또한 좋아할 수 있습니다

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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