H11-CAG-LSL-Myc
모델명
C57BL/6Smoc-Igs2em1(CAG-LSL-Myc)Smoc
카탈로그
NM-KI-00039
모델 상태
Repository Live
유전자 요약
Official Symbol
모델 설명
검증 데이터
Using the Crispr technology, the conditional overexpression structure of CAG promoter-loxp-STOP-loxp-Myc-polyA was inserted into the H11 locus to generate an H11-LSL-Myc mouse model. Located on mouse chromosome 11, the H11 locus is similar to Rosa26 and can be used to express a wide range of exogenous genes. The Myc gene can be highly expressed in Cre-expressing tissues after mating the H11-LSL-Myc mice with Cre mice.
For example: After mating H11-LSL-Myc mice with Alb-cre mice, a liver cancer can be spontaneously developed at 2 months old. This mouse model can be used in the establishment of tumor models and tumor research.
Fig1. Schematic diagram of H11-LSL-Myc knockin cassette.
Fig2 Representative in vivo bioluminescence imaging showing the growth of tumors in C57BL/6 mice inoculated with hepatocellular carcinoma tissue from H11-LSL-Myc; Rosa26-LSL-Luc-EGFP; Alb-Cre mice.
간행물
당신은 또한 좋아할 수 있습니다
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
조회