Rag2-KO
모델명
C57BL/6Smoc-Rag2em2Smoc
카탈로그
NM-KO-190429
모델 상태
Repository Live
유전자 요약
Official Symbol
Rag2
모델 설명
Partial exon 3 of Rag2 gene was deleted to generate Rag2 knockout mice. Deletion of this region will cause frameshift and result in loss of function of mouse Rag2 gene.
Disease Connection
검증 데이터
Figure 1. Loss of T,B cells in Rag2(-/-) mice.
Splenocytes and blood cells of Rag2 knockout mice were isolated. Fractions of T and B cells were characterized using flow-cytometry.
간행물
E4BP4-mediated inhibition of T follicular helper cell differentiation is compromised in autoimmune diseases
References:The Journal of Clinical Investigation
Induction of Foxp3 and activation of Tregs by HSP gp96 for treatment of autoimmune diseases
References:iScience
당신은 또한 좋아할 수 있습니다
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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