hIL4-Tg(NMG)
모델명
NOD-PrkdcscidIl2rgem1Tg(hIL4)Smoc
카탈로그
NM-KI-215004
모델 상태
Embryo cryopreservation
유전자 요약
Official Symbol
IL4
모델 설명
These transgenic mice carry humanized IL4.
검증 데이터
Fig1. Detection of hIL4 expression by RT-PCR.
Heterozygous: one band at 223 bp with primers F1/R1(hIL4);
Abbr. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
Fig 2. Detection of hIL4 expression in serum by ELISA.
Abbr. HO, homozygous; HE, heterozygous; WT, wild type.、
Fig 3. Body weight growth curve of huPBMC-M-NSG-hIL4 mice.
Fig 4. Survival rate of huPBMC-M-NSG-hIL4 mice.
Fig 5. GvHD scores of huPBMC-M-NSG-hIL4 mice.
Fig 6. Percentage of hCD45-positive cells in peripheral blood of huPBMC-M-NSG-hIL4 mice.
Fig 7. Flow analysis of peripheral blood lymphocyte subpopulations in the huPBMC-M-NSG-hIL4 model. Human PBMCs (1E7) were injected intravenously into hIL4-Tg(M-NSG) mice (female, 6-8 weeks old, n=10). Blood from mice at different time points after implantation of human PBMCs was taken for flow cytometric analysis.
당신은 또한 좋아할 수 있습니다
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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