MHCII/B2m-KO(NMG)
모델명
NOD.Cg-PrkdcscidIl2rgem1SmocH2-Ab1em1SmocH2-Aaem1SmocH2-Eb1em1SmocH2-Eb2em1SmocH2-Ea-psem1SmocB2mem1Smoc
카탈로그
NM-NSG-014
모델 상태
Repository Live
유전자 요약
Official Symbol
B2M
Official Symbol
MHCII(H2-Ab1; H2-Aa; H2-Eb1; H2-Eb2; H2-Ea)
모델 설명
All sequences from the upstream of mouse H2-Ab1 gene exon 2 to the upstream of the H2-Ea-ps gene exon 1 were knocked out to obtain H2-Ab1、H2-Aa、H2-Eb1、H2-Eb2、H2-Ea-ps knockout mouse models.Also, B2m gene was knocked out. These MHC class I and II molecule-deficient mice were on the NMG genetic background and also lacked cell surface expression of both class II-A and class II-E MHC proteins and B2m of class I.
검증 데이터
Fig1. Detection of MHCII and B2m expression in spleen in MHCII/B2M-dKO (M-NSG) mice by RT-PCR.
Fig2. Expression characterization of mouse MHC I and MHC II in MHCII/B2M-dKO (M-NSG) mice.
당신은 또한 좋아할 수 있습니다
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
조회