Sftpc-IRES-rtTA

모델명

C57BL/6Smoc-Sftpcem2(Avitag-IRES-V5-M2rtTA-WPRE-polyA)Smoc

카탈로그

NM-KI-18043

모델 상태

Sperm cryopreservation

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유전자 요약

Official Symbol
Sftpc

Synonyms

SP5， SPC， SP-C， Sftp2， Bricd6， Sftp-2， pro-SpC

NCBI ID

20389

MGI ID

109517

Ensembl ID

ENSMUSG00000022097

Pubmed

Sftpc

Human Ortholog

SFTPC

모델 설명

An Avitag-IRES-V5-M2rtTA-WPRE-polyA expression cassette was knocked into the Sftpc gene stop codon site by homologous recombination.

검증 데이터

sftpc-1.png

Fig1. Expression Pattern of EGFP in Sftpc -M2rtTA; pTRE-H2BGFP mice.

Sftpc -M2rtTA mice express the reverse tetracycline-controlled transactivator (rtTA) protein under the control of the mouse surfactant, pulmonary-associated protein C (Sftpc) promoter, and expression of the target gene may be regulated by the tetracycline analog, doxycycline. This strain provides a Tet-On tool that allows the inducible expression of genes in the developing and adult lung and respiratory epithelium.

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Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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