hAppNL-G-F

모델명

C57BL/6Smoc-Apptm3(hAppNL-G-F)/Smoc

카탈로그

NM-HU-2000088

모델 상태

Embryo cryopreservation

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유전자 요약

Official Symbol
App

Synonyms

Ag; Abpp; Adap; Cvap; Abeta; betaApp; E030013M08Rik

NCBI ID

11820

MGI ID

88059

Ensembl ID

ENSMUSG00000022892

Pubmed

App

Human Ortholog

APP

모델 설명

The endogenous mouse App gene was replaced by human AppNL-G-F.
신청분야：Alzheimer's disease research

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Fig1. Detection of APP expression in brain by RT-PCR.

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Fig2. (A) β-Amyloid (6E10) staining of WT and hAPPNL-G-F mice at 1, 3 and 6 months (magnification, 40x and 100x). (B) Statistics of 6E10 positive plaque area.

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Fig3. (A) Thioflavine S staining of WT and hAPPNL-G-F mice at 1, 3 and 6 months (magnification, 40x and 100x). (B) Statistics of ThiS positive plaque area.

당신은 또한 좋아할 수 있습니다

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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