hIL17A/hIL17F
모델명
C57BL/6Smoc-Il17atm1(hIL17A)Il17fem2(hIL17F)Smoc
카탈로그
NM-HU-200281
모델 상태
Embryo cryopreservation
유전자 요약
Official Symbol
IL17A
Official Symbol
IL17F
모델 설명
검증 데이터
Fig1. Analysis of IL17F gene expression in the kidney by RT-PCR. Mouse Il17f mRNA was detectable by P1/2(440bp), human IL17F mRNA was detectable by P3/4(259bp), M:100bp Plus DNA ladder from Transgen (BM311). The heterozygous KI mice express both human IL17F and mouse Il17f in the kidney.
Fig2. Analysis of IL17A gene expression in the spleen by RT-PCR in WT and IL17A/IL17F humanized mice . Mouse Il17a mRNA was detectable by P1/2(490bp), human IL17A mRNA was detectable by P3/4(443bp), M:100bp Plus DNA ladder from Transgen (BM311). The heterozygous KI mouse expresses both human IL17A and mouse Il17a in the spleen.
Fig. 3 Detection of hIL17A expression in serum, spleen and thymus homogenate by ELISA (n=3).
Abbr. HO, homozygous; WT, wild type.
Note. hIL17A/hIL17F and C57BL/6 mice were i.p. injected with LPS.
Fig. 4 Detection of hIL17F expression in serum, spleen and thymus homogenate by ELISA (n=3).
Abbr. HO, homozygous; WT, wild type.
Note. hIL17A/hIL17F and C57BL/6 mice were i.p. injected with LPS.
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On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
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