Cdkn2a-Flox(p19-Flox)

모델명

C57BL/6Smoc-Cdkn2aem1(flox)Smoc

카탈로그

NM-CKO-200151

모델 상태

Sperm cryopreservation

PDF 받기

유전자 요약

Official Symbol
Cdkn2a

Synonyms

Arf; p16; MTS1; Pctr1; p19ARF; p16INK4a; p19; ARF-INK4a; INK4a-ARF; Ink4a/Arf; p16(INK4a)

NCBI ID

12578

MGI ID

104738

Ensembl ID

ENSMUSG00000044303

Pubmed

Cdkn2a

Human Ortholog

CDKN2A

모델 설명

These mice carry loxP sites flanking exon 1 of Cdkn2a-p19ARF transcript.
신청분야：Research on protein metabolism and ERK signal transduction

Disease Connection

Melanoma

Phenotype(s)

MGI:5603215
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Tyr-cre/ERT mice.

Reference(s)

Huijbers IJ, Krimpenfort P, Chomez P, van der Valk MA, Song JY, Inderberg-Suso EM, Schmitt-Verhulst AM, Berns A, Van den Eynde BJ, An inducible mouse model of melanoma expressing a defined tumor antigen. Cancer Res. 2006 Mar 15;66(6):3278-86

melanoma

Phenotype(s)

MGI:4418448
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Pten-Flox(NM-CKO-18004) and Tyr-cre/ERT2 mice.

Reference(s)

Held MA, Curley DP, Dankort D, McMahon M, Muthusamy V, Bosenberg MW, Characterization of melanoma cells capable of propagating tumors from a single cell. Cancer Res. 2010 Jan 1;70(1):388-97

Alveolar Rhabdomyosarcoma

Phenotype(s)

MGI:3844659
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Pax3-Flox(NM-CKO-2101872) and Myf6-Cre mice.

Reference(s)

Keller C, Arenkiel BR, Coffin CM, El-Bardeesy N, DePinho RA, Capecchi MR, Alveolar rhabdomyosarcomas in conditional Pax3:Fkhr mice: cooperativity of Ink4a/ARF and Trp53 loss of function. Genes Dev. 2004 Dec 1;18(21):2614-26

Skin Melanoma

Phenotype(s)

MGI:5752239
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Nras-Flox(NM-CKO-2100519)，Stk11-Flox(2)(NM-CKO-200251) and Tyr-cre/ERT2 mice.

Reference(s)

Burd CE, Liu W, Huynh MV, Waqas MA, Gillahan JE, Clark KS, Fu K, Martin BL, Jeck WR, Souroullas GP, Darr DB, Zedek DC, Miley MJ, Baguley BC, Campbell SL, Sharpless NE, Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma. Cancer Discov. 2014 Dec;4(12):1418-29

skin melanoma

Phenotype(s)

MGI:5752235
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Nras-Flox(NM-CKO-2100519) and Tyr-cre/ERT2 mice.

Reference(s)

Burd CE, Liu W, Huynh MV, Waqas MA, Gillahan JE, Clark KS, Fu K, Martin BL, Jeck WR, Souroullas GP, Darr DB, Zedek DC, Miley MJ, Baguley BC, Campbell SL, Sharpless NE, Mutation-specific RAS oncogenicity explains NRAS codon 61 selection in melanoma. Cancer Discov. 2014 Dec;4(12):1418-29

Sarcoma

Phenotype(s)

MGI:5792147
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Nf1-Flox(NM-CKO-200018) and Ad-Cre mice.

Reference(s)

Dodd RD, Mito JK, Eward WC, Chitalia R, Sachdeva M, Ma Y, Barretina J, Dodd L, Kirsch DG, NF1 deletion generates multiple subtypes of soft-tissue sarcoma that respond to MEK inhibition. Mol Cancer Ther. 2013 Sep;12(9):1906-17

Pancreatic Ductal Adenocarcinoma

Phenotype(s)

MGI:5308951
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Kras-LSL-G12D(NM-KI-190003)，P53-Flox(2)(NM-CKO-190067) and Pdx1-cre mice.

Reference(s)

Bardeesy N, Aguirre AJ, Chu GC, Cheng KH, Lopez LV, Hezel AF, Feng B, Brennan C, Weissleder R, Mahmood U, Hanahan D, Redston MS, Chin L, Depinho RA, Both p16(Ink4a) and the p19(Arf)-p53 pathway constrain progression of pancreatic adenocarcinoma in the mouse. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5947-52

Pancreatic Carcinoma

Phenotype(s)

MGI:5441554
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Kras-LSL-G12D(NM-KI-190003) and Pdx1-cre mice.

Reference(s)

Singh M, Couto SS, Forrest WF, Lima A, Cheng JH, Molina R, Long JE, Hamilton P, McNutt A, Kasman I, Nannini MA, Reslan HB, Cao TC, Ho CC, Barck KH, Carano RA, Foreman O, Eastham-Anderson J, Jubb AM, Ferrara N, Johnson L, Anti-VEGF antibody therapy does not promote metastasis in genetically engineered mouse tumour models. J Pathol. 2012 Aug;227(4):417-30

Pancreatic Ductal Adenocarcinoma

Phenotype(s)

MGI:2687217
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Kras-LSL-G12D(NM-KI-190003) and Pdx1-cre mice.

Reference(s)

Aguirre AJ, Bardeesy N, Sinha M, Lopez L, Tuveson DA, Horner J, Redston MS, DePinho RA, Activated Kras and Ink4a/Arf deficiency cooperate to produce metastatic pancreatic ductal adenocarcinoma. Genes Dev. 2003 Dec 15;17(24):3112-26

Melanoma

Phenotype(s)

MGI:4418449
Note：The expected phenotype(s) may be observed in the above-mentioned mice that bred with Ctnnb1-Flox(NM-CKO-200154)，Pten-Flox(NM-CKO-18004) and Tyr-cre/ERT2 mice.

Reference(s)

Held MA, Curley DP, Dankort D, McMahon M, Muthusamy V, Bosenberg MW, Characterization of melanoma cells capable of propagating tumors from a single cell. Cancer Res. 2010 Jan 1;70(1):388-97

당신은 또한 좋아할 수 있습니다

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

조회
Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

조회