hIL2/hIL2RA

모델명

C57BL/6Smoc-Il2tm3(hIL2)Il2ratm1(hIL2RA)/Smoc

카탈로그

NM-HU-200275

모델 상태

Embryo cryopreservation

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유전자 요약

Official Symbol

Synonyms

Il-2，I， CD25， Il2r， Ly-4， Ly-43

NCBI ID

16183，16184

MGI ID

96548，96549

Ensembl ID

ENSMUSG00000027720，ENSMUSG00000026770

Pubmed

Human Ortholog

IL-2，IL2RA

모델 설명

hIL2(NM-HU-190048) was crossed with hIL2R(NM-HU-190064) to generate IhIL2/hIL2RA mice.

검증 데이터

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Fig1. Detection of hIL-2 expression by ELISA in the hIL-2 knockin mice (Wild type and heterozygous hIL-2 KI mice were administrated with concanavalin).

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Fig2. Intracellular staining of IL-2 by FACS post stimulation with anti-mCD3/anti-mCD28 (In collaboration with CrownBio).

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Fig3. IL-2RA humanized mouse expresses hlL-2RA (hCD25) on naïve Treg in blood (In collaboration with CrownBio).

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Fig4. hlL-2RA is highly expressed on activated Tregs in spleen in the IL-2RA huamnzied mouse (In collaboration with CrownBio).

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Fig5. hlL-2RA is highly expressed on activated NK cells in spleen in the IL-2RA humanized mouse (In collaboration with CrownBio).

당신은 또한 좋아할 수 있습니다

Shanghai Model Organisms Center Inc has licensed CRISPR-Cas9 technology from Broad Institute

On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.

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Milestones

Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.

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