Il2-IRES-Venus-Luc
모델명
C57BL/6Smoc-Il2em1(Venus-Luci)Smoc
카탈로그
NM-KI-18057
모델 상태
Embryo cryopreservation
유전자 요약
Official Symbol
Il2
모델 설명
검증 데이터
Fig1.Hepa1-6 tumor volumes in Il2-Venus-Luci reporter mice treated or not with anti-PD-1 mAb. Arrows indicate treatment days.
Fig2. In vivo imaging validation of Hepa1-6 tumors in Il2-Venus-Luci reporter mice treated or not with anti-PD-1 mAb.
In PBS treated group, the IL2 signal increased as the tumor development, which indicated an inflamed immune environment. In the PD1 mAb treated group, the IL2 signal is enhanced, especially at day 21.
Fig3. IL2 signal in ventral position of Il2-Venus-Luci reporter mice.
IL2 signal from abdomen is higher in PD1 treated mice than control mice on day 21. The signal should be produced by immune cells in mesenteric lymph nodes.
Fig4. Tissue IL2 signal in the Il2-Venus-Luci reporter mice at termination.
Tumor draining lymph node(TDLN) from PD1 treated mice have significantly higher IL2 signal than control mice. While tumor and spleen showed lowered or comparable IL2 signal compared to control mice.
The data is provided by Crownbio.
당신은 또한 좋아할 수 있습니다
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
조회