hCSF1R(2)
모델명
C57BL/6Smoc-Csf1rem3(hCSF1R)Smoc
카탈로그
NM-HU-190074
모델 상태
Embryo cryopreservation
유전자 요약
Official Symbol
CSF1R
모델 설명
검증 데이터
Fig1. Detection of CSF1R(2) expression in spleen by RT-PCR. Wild type: only one band at 233 bp with primers F1/R1(mCsf1r(2));Homozygous: only one band at 345 bp with primers F2/R2(hCSF1R(2)); Abbr.. M, DNA marker; HO, homozygous; HE, heterozygous; WT, wild type.
Fig2. Detection of hCSF1R expression in blood and bone marrow in hCSF1R(2) KI mice.
Fig3. FPA008 and human CSF-1R test Ab can effectively inhibit the growth of bone marrow cells in hCSF1R mice, confirming that this model is an appropriate platform for human anti-CSF-1R antibody evaluation.（FPA008，BMS，phase II）
Fig4. Dose-dependent effect of huCSF-1R inhibitors on block the proliferation of macrophages in hCSF1R mice.
당신은 또한 좋아할 수 있습니다
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
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