hIL2/hIL2RA/hIL2RB/hIL2RG
모델명
C57BL/6Smoc-Il2tm3(hIL2)Il2ratm1(hIL2RA)Il2rgem1(IL2RG)Il2rbtm1(hIL2RB)Smoc
카탈로그
NM-HU-210415
모델 상태
Repository Live
유전자 요약
Official Symbol
IL2
Official Symbol
IL2RA
Official Symbol
IL2RB
Official Symbol
IL2RG
Official Symbol
Il2ra
모델 설명
검증 데이터
Fig1. Detection of hIL-2 expression by ELISA in the hIL-2 knockin mice (Wild type and heterozygous hIL-2 KI mice were administrated with concanavalin).
Fig2. Intracellular staining of IL-2 by FACS post stimulation with anti-mCD3/anti-mCD28 (In collaboration with CrownBio).
Fig3. IL-2RA humanized mouse expresses hlL-2RA (hCD25) on naïve Treg in blood (In collaboration with CrownBio).
Fig4. hlL-2RA is highly expressed on activated Tregs in spleen in the IL-2RA huamnzied mouse (In collaboration with CrownBio).
Fig5. hlL-2RA is highly expressed on activated NK cells in spleen in the IL-2RA humanized mouse (In collaboration with CrownBio).
Fig6. Immunotype in hIL2/hIL2RA/hIL2RB/hIL2RG qKI mice.
Fig7. Immunotype in hIL2/hIL2RA/hIL2RB/hIL2RG qKI mice in Blood.
Fig8. Immunotype in hIL2/hIL2RA/hIL2RB/hIL2RG qKI mice in Spleen.
Fig9. Detection of Signaling integrity in hIL2/hIL2RA/hIL2RB/hIL2RG qKI mice.
Note. Splenocytes of C57BL/6 mice were treated with anti-mCD3 and mIL-2(10 ng/ml) for 72h. Splenocytes of hIL2/hIL2RA/hIL2RB/hIL2RG qKI mice were treated with anti-mCD3 and hIL-2(10 ng/ml) for 72h.
당신은 또한 좋아할 수 있습니다
On Dec 16, 2018, Broad Institute and Shanghai Model Organisms Center Inc (SMOC) has entered into a non-exclusive license agreement under which Broad has granted SMOC worldwide rights to commercialize a service platform for genetically modified mouse models under Broad's intellectual property.
조회Our vision is to provide researchers all over the world with comprehensive, convenient and professional animal model services to facilitate a simplified and highly-efficient approach towards uncovering the mysteries of life.
조회