1. 홈페이지
  2. 模型资源
  3. 成品模型
  4. 疾病小鼠（U-DMbase®）
  5. 代谢心血管疾病模型

U-GEMMs

代谢心血管疾病模型

代谢心血管疾病包括2型糖尿病、心脏代谢紊乱、高脂血症、动脉粥样硬化、高血压等，这类慢性病严重影响人的生活质量，并会带来沉重的经济负担。南模生物自主构建了多种代谢心血管疾病模型小鼠，可助力代谢心血管疾病的基础研究和药物开发。

마우스
R26-CAG-LSL-hSOX2-IRES-Luc-2A-EGFP/Kras-LSL-G12D
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm(CAG-LSL-SOX2-IRES-Luciferase-2a-EGFP-WPRE-polyA)Krasem4(LSL-G12D)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-234153
마우스
R26-CAG-LSL-hTM6SF2*E167K-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-Frt-2xpolyA-CAG-Frt-LSL-TM6SF2-IRES-GFP-WPRE-PA)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-200017
신청분야：Non-alcoholic fatty liver disease
마우스
R26-CAG-LSL-hTPM3-NTRK1-IRES-Luc-2A-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm(SA-polyA-CAG-LSL-TPM3-NTRK1-IRES-luc-2A-tdTomato-WPRE-polyA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-190098
신청분야：Colorectal carcinoma related.
마우스
R26-CAG-LSL-Kras*G12C-IRES-Luc
모델명：C57BL/6JSmo-Gt(ROSA)26Sorem1(CAG-FRT-LSL-Kras(G12C)-IRES-Luciferase-polyA)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-200323
마우스
R26-CAG-LSL-Kras*G12C-IRES-Luc(BALB/c)
모델명：BALB/cJSmo-Gt(ROSA)26Sorem2(CAG-FRT-LSL-Kras(G12C)-IRES-Luciferase-polyA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-200324
마우스
R26-CAG-LSL-Luc-2A-EGFP/Trp53-Flox/Kras-LSL-G12D
모델명：C57BL/6JSmo-Gt(ROSA)26Sorem1(CAG-LSL-Luciferase-2A-EGFP-wpre-polyA)Trp53tm2(flox)Krasem4(LSL-G12D)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-234519
마우스
R26-LSL-Notch1C-IRES-nEGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sorem1(SA-LSL-Notch1C-IRES-nEGFP)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-200036
신청분야：Spontaneous tumor model
마우스
R26-LSL-SmoM2W539L-IRES-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sorem1(SA-loxp-stop-loxp-SmoM2(W539L)-IRES-tdTomato-WPRE-polyA)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-200035
신청분야：Medulloblastoma
마우스
Smad4-Flox
모델명：C57BL/6JSmo-Smad4tm1(flox)Smoc
모델 상태：Repository Live | 카탈로그：NM-CKO-18011
Disease Connection：osteogenesis imperfecta, squamous cell carcinoma, stomach cancer
마우스
Trp53-Flox
모델명：C57BL/6JSmo-Trp53tm2(flox)Smoc
모델 상태：Repository Live | 카탈로그：NM-CKO-18005
Disease Connection：medulloblastoma, breast cancer, prostate cancer, central nervous system cancer, osteosarcoma, pancreatic carcinoma, malignant astrocytoma, thyroid gland carcinoma, ovarian cancer, urinary bladder cancer, alveolar rhabdomyosarcoma, glioblastoma, pancreatic ductal adenocarcinoma, squamous cell carcinoma, thyroid gland cancer, CHARGE syndrome, stomach cancer, invasive lobular carcinoma, endometrial cancer, hereditary breast ovarian cancer syndrome, pancreatic mucinous cystadenoma
위로 点击跳转到顶部