1. 홈페이지
  2. Models
  3. U-GEMMs
  4. Standard GEMMs
  5. Point Mutation Knockins

Models

Point Mutation Knockins

Point mutant knockin mouse model is a mouse in which one or more nucleotides are replaced by mutant nucleotides in the genome. This may result in amino acid changes within the protein sequence, and transcription terminated, thereby significantly affecting the normal function of the protein. Point mutation mouse models are widely used to study the role of specific nucleotides or amino acids in genetic elements or proteins, as well as to mimic human genetic diseases.

마우스
Aars2-R194C
모델명：C57BL/6JSmo-Aars2em(R194C)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-230024
마우스
Abcc8-L1050R/S1051N/P1052C/A1053*
모델명：C57BL/6JSmo-Abcc8tm1(L1050R/S1051N/P1052C/A1053*)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-232146
마우스
Abcc8-V1049Q/L1050S/S1051*
모델명：C57BL/6JSmo-Abcc8tm1(Abcc8-V1049Q/L1050S/S1051*)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-232145
마우스
Abtb2-L849P
모델명：C57BL/6JSmo-Abtb2em(L849P)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-210362
마우스
Acadm-repeat(E8-10)
모델명：C57BL/6JSmo-Acadmem1(E8-10 repeat)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-200239
Disease Connection：medium chain acyl-CoA dehydrogenase deficiency
마우스
Akt1-C224S
모델명：C57BL/6JSmo-Akt1em(C224S)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-215096
마우스
Apc-L850X
모델명：C57BL/6JSmo-Apcem1(L850X)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-200001
Disease Connection：familial adenomatous polyposis, colorectal cancer, Lynch syndrome
마우스
Apex1-C64S
모델명：C57BL/6JSmo-Apex1tm1C64SSmoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-232235
마우스
Apob-Q1388H
모델명：C57BL/6JSmo-Apobem1(Q1388H)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-00056
신청분야：lipid metabolism studies, cardiovascular disease research
마우스
Atp7b-H1071Q
모델명：C57BL/6JSmo-Atp7bem1(H1071Q)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-18001
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