1. 홈페이지
  2. Models
  3. U-GEMMs
  4. Standard GEMMs
  5. Point Mutation Knockins

Models

Point Mutation Knockins

Point mutant knockin mouse model is a mouse in which one or more nucleotides are replaced by mutant nucleotides in the genome. This may result in amino acid changes within the protein sequence, and transcription terminated, thereby significantly affecting the normal function of the protein. Point mutation mouse models are widely used to study the role of specific nucleotides or amino acids in genetic elements or proteins, as well as to mimic human genetic diseases.

마우스
Trem2-R47H
모델명：C57BL/6JSmo-Trem2em3(p.R47H)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-190092
신청분야：Neurobiology Research,Alzheimer's disease related
마우스
Trem2-R62H
모델명：C57BL/6JSmo-Trem2em1(R62H)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-210225
마우스
Trex1-D18N
모델명：C57BL/6JSmo-Trex1em1D18NSmoc
모델 상태：Repository Live | 카탈로그：NM-KI-231599
마우스
Trp53-FSF-R270H
모델명：C57BL/6JSmo-Trp53tm(Frt-Stop-Frt-R270H)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-210364
마우스
Trp53-LSL-R270H
모델명：C57BL/6JSmo-Trp53tm7(R270H-flox)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-200186
신청분야：Cancer research
마우스
Trp53-R172H
모델명：C57BL/6JSmo-Trp53em4(R172H)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-18028
신청분야：cancer research
마우스
Trp53-R172H/Kras-LSL-G12D(2)
모델명：C57BL/6JSmo-Trp53em4(R172H)Krasem4(LSL-G12D)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-230388
마우스
Trp53-R245W
모델명：C57BL/6JSmo-Trp53em(R245W)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-225098
마우스
Trp53-R270H
모델명：C57BL/6JSmo-Trp53em3(R270H)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-18027
신청분야：cancer research
마우스
Trpm2-D1066A
모델명：C57BL/6JSmo-Trpm2em(D1066A)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-215101
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