1. 홈페이지
  2. Models
  3. U-GEMMs
  4. Standard GEMMs
  5. Point Mutation Knockins

Models

Point Mutation Knockins

Point mutant knockin mouse model is a mouse in which one or more nucleotides are replaced by mutant nucleotides in the genome. This may result in amino acid changes within the protein sequence, and transcription terminated, thereby significantly affecting the normal function of the protein. Point mutation mouse models are widely used to study the role of specific nucleotides or amino acids in genetic elements or proteins, as well as to mimic human genetic diseases.

마우스
hHBB-E7V
모델명：C57BL/6JSmo-hHBBtm1(E7V)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-233577
마우스
hMAPT-P301S
모델명：C57BL/6JSmo-Mapttm1(hMAPT-P301S)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-233262
마우스
Ifng-del(162bp)
모델명：C57BL/6JSmo-Ifngem1(162bp-del)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-210223
마우스
Il6st-Y757F/V760A
모델명：C57BL/6JSmo-Il6stem(Y757F-V760A)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-220045
마우스
Ins2-C96Y
모델명：C57BL/6JSmo-Ins2em3(C96Y)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-190096
Disease Connection：diabetes
마우스
Jak2-Flox-V617F
모델명：C57BL/6JSmo-Jak2tm1(Flox-V617F)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-210367
마우스
Jak2-Flox-V617F(2)
모델명：C57BL/6JSmo-Jak2em(flox-V617F)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-220009
마우스
Kit-V831M
모델명：C57BL/6JSmo-Kitem2(V831M)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-190023
신청분야：hematopoieticstem cell 
마우스
Kit-V831M(NOD-scid)
모델명：NOD-PrkdcscidKitem1(V831M)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-200316
신청분야：Hematopoieticstem cell
마우스
Kras-LSL-G12D
모델명：C57BL/6JSmo-Krasem4(LSL-G12D)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-190003
Disease Connection：squamous cell carcinoma, prostate cancer, pancreatic carcinoma, neurofibromatosis, pancreatic ductal adenocarcinoma, juvenile myelomonocytic leukemia, urinary bladder cancer, ovarian cancer
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