1. 홈페이지
  2. Models
  3. U-GEMMs
  4. Standard GEMMs
  5. Point Mutation Knockins

Models

Point Mutation Knockins

Point mutant knockin mouse model is a mouse in which one or more nucleotides are replaced by mutant nucleotides in the genome. This may result in amino acid changes within the protein sequence, and transcription terminated, thereby significantly affecting the normal function of the protein. Point mutation mouse models are widely used to study the role of specific nucleotides or amino acids in genetic elements or proteins, as well as to mimic human genetic diseases.

마우스
Kras-RSR-G12D
모델명：C57BL/6JSmo-Krastm(Rox-Stop-Rox-G12D)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-210436
마우스
Lat-Y136F
모델명：C57BL/6JSmo-Latem1(Y136F）Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-200249
Disease Connection：IgG4-related disease
마우스
Ldlr-C223R
모델명：C57BL/6JSmo-Ldlrem1(C223R)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-00043
신청분야：Metabolic and cardiovascular disease research
마우스
Lep-R105X
모델명：C57BL/6JSmo-Lepem(R105X)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-230475
마우스
Lep-R105X(BALB/c)
모델명：BALB/cJSmo-Lepem(R105X)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-230476
마우스
Lepr-g.G109052T
모델명：B6.129S-Leprtm1Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-00001
신청분야：Leptin resistance,insulin resistance,obesity,and type 2 diabetes etc.
마우스
Lmna-c.C1827T
모델명：C57BL/6JSmo-Lmnatm1(G609G)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-200284
Disease Connection：progeria
마우스
Lrrk2-P1446L
모델명：C57BL/6JSmo-Lrrk2em(P1446L)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-215098
마우스
Mapt-R5H
모델명：C57BL/6JSmo-Maptem(R5H)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-215099
마우스
Mcm7-R43Q
모델명：C57BL/6JSmo-Mcm7em1R43QSmoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-233284
위로 点击跳转到顶部