1. 홈페이지
  2. Models
  3. U-GEMMs
  4. Standard GEMMs
  5. Point Mutation Knockins

Models

Point Mutation Knockins

Point mutant knockin mouse model is a mouse in which one or more nucleotides are replaced by mutant nucleotides in the genome. This may result in amino acid changes within the protein sequence, and transcription terminated, thereby significantly affecting the normal function of the protein. Point mutation mouse models are widely used to study the role of specific nucleotides or amino acids in genetic elements or proteins, as well as to mimic human genetic diseases.

마우스
Clcc1-K298A
모델명：C57BL/6JSmo-Clcc1tm1K298ASmoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-234160
마우스
Col4a5-R373X
모델명：C57BL/6JSmo-Col4a5em1(R373X)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-200296
마우스
Col4a5-R471X
모델명：C57BL/6JSmo-Col4a5em1(R471X)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-200183
Disease Connection：X-linked Alport syndrome
마우스
Cpa1-N256K
모델명：
모델 상태： | 카탈로그：
마우스
Crbn-I391V
모델명：C57BL/6JSmo-Crbnem1(I391V)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-200331
마우스
Crbn-I391V/Rag2-KO
모델명：C57BL/6JSmo-Crbnem1(I391V)Rag2em2Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-210398
마우스
Crbn-V380E
모델명：C57BL/6JSmo-Crbnem(V380E)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-210370
마우스
Dhtkd1-Y485X
모델명：B6;129S-Dhtkd1tm1Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-00005
마우스
Dmd-Q995X
모델명：C57BL/6JSmo-Dmdem1(Q995X)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-18026
Disease Connection：Duchenne muscular dystrophy
마우스
Dnmt3a-LSL-R878H
모델명：C57BL/6JSmo-Dnmt3atm1(LSL-R878H)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-230147
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