1. 홈페이지
  2. Models
  3. U-GEMMs
  4. Standard GEMMs
  5. Humanized Knockins
  6. Metabolic Targets

Models

Metabolic Targets

SMOC has developed a set of mouse models expressing humanized metabolic targets. These models are suitable to assess the efficacy of drugs targeting metabolic pathways proteins in fully immunocompetent mice.

마우스
pAlb-hLPA-Tg(V3)
모델명：C57BL/6JSmo-Tg(pAlb-hLPA-WPRE-pA)1Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-TG-232196
마우스
R26-CAG-LSL-hAR-IRES-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(R26-CAG-Loxp-Stop-Loxp-hAR-IRES-EGFP-WPRE-pA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-215053
마우스
R26-CAG-LSL-hBCR/ABL
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-loxp-STOP-loxp-BCR-ABL-IRES-Luciferase-2A-tdTomato-WPRE-polyA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-190127
신청분야：Chronic Myelocytic Leukemia(CML) research
마우스
R26-CAG-LSL-hETV6/NTRK3-IRES-Luc-2A-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-polyA-CAG-LSL-ETV6-NTRK3-IRES-luc-2A-tdTomato-WPRE-polyA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-190107
신청분야：cancer research
마우스
R26-CAG-LSL-hIDH1*R132H-IRES-Luc-2A-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-IDH1(R132H)-IRES-Luciferase-2A-tdTomato)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-190074
신청분야：cancer research
마우스
R26-CAG-LSL-hMLL-AF9-IRES-Luc-2A-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-FRT-2xpA-CAG-FRT-loxp-STOP-loxp-MLL-AF9-IRES-Luciferase-2A-tdTomato-WPRE-polyA)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-190114
신청분야：Acute myelogenous leukemia model
마우스
R26-CAG-LSL-hPNPLA3-I148M-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-Frt-2xpolyA-CAG-Frt-LSL-hPNPLA3 I148M-IRES-GFP-wpre-polyA)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-200013
신청분야：rs738409：148 isoleucine to Methionine protein variant,I148M.Non-alcoholic fatty liver and hepatitis B cirrhosis research.
마우스
R26-CAG-LSL-hSOD1*G94A-IRES-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-FRT-LSL- SOD1(G94A)-IRES-EGFP-WPRE-pA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-200263
Disease Connection：amyotrophic lateral sclerosis type 1
마우스
R26-CAG-LSL-hTERT-IRES-Luc-2A-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-V5-TERT-IRES-Luciferase-2A-EGFP-WPRE-pA)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-18035
신청분야：Telomerase
마우스
R26-CAG-LSL-hTM6SF2*E167K-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-Frt-2xpolyA-CAG-Frt-LSL-TM6SF2-IRES-GFP-WPRE-PA)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-200017
신청분야：Non-alcoholic fatty liver disease
위로 点击跳转到顶部