1. 홈페이지
  2. Models
  3. U-GEMMs
  4. Standard GEMMs
  5. Humanized Knockins
  6. Tumor Targets

Models

Tumor Targets

Humanized tumor target mice are immunocompetent chimeric mouse models, engineered to express humanized tumor targets such as genes encoding for oncogene proteins, tumor suppressor proteins, tumor specific antigen, etc. These models can can be used to evaluate the risk of on-target, off-tumor toxicities for targeted cancer drug.

마우스
R26-CAG-LSL-hHER2*ex20ins-IRES-Luc-2A-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-ERBB2(exon20 insertion)-IRES-Luciferase-2A-EGFP)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-190071
신청분야：cancer research
마우스
R26-CAG-LSL-hHER2-IRES-Luc-2A-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-2xpolyA-CAG-LSL-HER2-luciferase-EGFP)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-190008
신청분야：cancer
마우스
R26-CAG-LSL-hIDH2*R140Q-IRES-Luc-2A-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-IDH2(R140Q)-IRES-Luciferase-2A-tdTomato)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-190075
Disease Connection：D-2-hydroxyglutaric aciduria
마우스
R26-CAG-LSL-hIDH2*R172K-IRES-Luci-2A-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-IDH2(R172K)-IRES-Luciferase-2A-tdTomato)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-190076
신청분야：cancer research
마우스
R26-CAG-LSL-hMET-IRES-Luc-2A-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-c-MET-IRES-luciferase-2A-tdTomato)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-18052
신청분야：Tumor research; drug screening
마우스
R26-CAG-LSL-hMSLN CDS-IRES-Luc
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-hMSLN-IRES-Luciferase-WPRE-pA)1Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-225094
마우스
R26-CAG-LSL-hMYCN-IRES-BFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm(CAG-LSL-HA-hMYCN-IRES-BFP-Wpre-polyA)1Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-225000
마우스
R26-CAG-LSL-hNFE2L2*G81S-IRES-Luc-2A-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-NFE2L2(G81S)-IRES-Luciferase-2A-tdTomato)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-190077
신청분야：cancer research
마우스
R26-CAG-LSL-hNRF2-IRES-Luc-2A-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-NRF2-IRES-luciferase-2A-tdTomato)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-18050
신청분야：Tumor research; drug screening
마우스
R26-CAG-LSL-hPIK3CA*H1047R-IRES-Luc-2A-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-PIK3CA(H1047R)-IRES-luciferase-2A-tdTomato)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-190065
Disease Connection：breast cancer, CLOVES syndrome, ovarian cancer, brain glioma
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