1. 홈페이지
  2. Models
  3. U-GEMMs
  4. Standard GEMMs
  5. Humanized Knockins
  6. Tumor Targets

Models

Tumor Targets

Humanized tumor target mice are immunocompetent chimeric mouse models, engineered to express humanized tumor targets such as genes encoding for oncogene proteins, tumor suppressor proteins, tumor specific antigen, etc. These models can can be used to evaluate the risk of on-target, off-tumor toxicities for targeted cancer drug.

마우스
R26-LSL-hEZH2-IRES-Luc-2A-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-EZH2-IRES-luciferase-2A-tdTomato)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-18053
신청분야：Tumor research; drug screening
마우스
R26-LSL-hNTN1
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-LSL-Kozak-hNTN1-WPRE-pA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-233967
마우스
R26-SA-LSL-hMycRTG3-ERT2-IRES-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-loxp-stop-loxp-hMycRTG3-ERT2-IRES-EGFP-WPRE-pA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-225096
마우스
Rab31-hRAB31*Y76F/Y86F/Y137F
모델명：C57BL/6JSmo-Rab31tm1(hRAB31*Y76F/Y86F/Y137F)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-210419
마우스
Rag2-KO/hVEGFR2
모델명：C57BL/6JSmo-Rag2em1Kdrtm2(hKDR)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-HU-200280
마우스
Rag2/IL2rg-KO/hVEGFR2
모델명：C57BL/6JSmo-Il2rgem1Rag2em1Kdrtm2(hKDR)Smoc
모델 상태：Repository Live | 카탈로그：NM-HU-220087
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