1. 홈페이지
  2. Models
  3. U-GEMMs
  4. Standard GEMMs
  5. Humanized Knockins
  6. Tumor Targets

Models

Tumor Targets

Humanized tumor target mice are immunocompetent chimeric mouse models, engineered to express humanized tumor targets such as genes encoding for oncogene proteins, tumor suppressor proteins, tumor specific antigen, etc. These models can can be used to evaluate the risk of on-target, off-tumor toxicities for targeted cancer drug.

마우스
R26-CAG-LSL-hPLAG1-IRES-Luc-2A-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-hPLAG1-IRES-Luciferase-2A-tdTomato-wpre-polyA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-215002
마우스
R26-CAG-LSL-hREST-IRES-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-REST-IRES-tdTomato-WPRE-polyA)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-200051
신청분야：Cancer and aging research
마우스
R26-CAG-LSL-hREST4-IRES-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-REST4-IRES-EGFP-WPRE-polyA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-200052
마우스
R26-CAG-LSL-hRHOA*Y42C-IRES-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-FRT-2xpolyA-CAG-FRT-LSL-RHOA(Y42C)-IRES-tdTomato-WPRE-polyA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-200048
신청분야：Cancer research
마우스
R26-CAG-LSL-hSOS-F-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-FRT-2xpolyA-CAG-FRT-loxp-Stop-loxp-SOS-F-IRES-tdTomato-WPRE-PA)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-200020
신청분야：Spontaneous skin cancer model
마우스
R26-CAG-LSL-hSOX2-IRES-Luc-2A-EGFP/Kras-LSL-G12D
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm(CAG-LSL-SOX2-IRES-Luciferase-2a-EGFP-WPRE-polyA)Krasem4(LSL-G12D)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-234153
마우스
R26-CAG-LSL-hTPM3-NTRK1-IRES-Luc-2A-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm(SA-polyA-CAG-LSL-TPM3-NTRK1-IRES-luc-2A-tdTomato-WPRE-polyA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-190098
신청분야：Colorectal carcinoma related.
마우스
R26-CAG-LSL-hWNT1
모델명：C57BL/6JSmo-Gt(ROSA)26Sorem1(SA-FRT-2xpA-CAG-FRT-loxp-STOP-loxp-WNT1-IRES-Luciferase-2A-tdTomato-WPRE-polyA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-190128
신청분야：Wnt1 signaling pathway, cancer research, etc
마우스
R26-CAG-LSL-SOX2-IRES-Luc-2A-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sorem(CAG-LSL-SOX2-IRES-Luciferase-2a-EGFP-WPRE-polyA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-210138
신청분야：Fluorescent reporter Mice
마우스
R26-hCD46-IRES-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-hCD46-IRES-tdTomato-polyA)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-190087
신청분야：Immune-related
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