1. 홈페이지
  2. Models
  3. U-GEMMs
  4. Standard GEMMs
  5. Humanized Knockins

Models

Humanized Knockins

The humanized knockin mouse model is a general term that refers to a mouse that has been engrafted with a short strand of human DNA. These strains may be used to streamline drug development, assess PK/PD of novel therapeutics, model human disease and explore pathogenic mechanisms, and more.

마우스
R26-CAG-LSL-hMSLN CDS-IRES-Luc
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-hMSLN-IRES-Luciferase-WPRE-pA)1Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-225094
마우스
R26-CAG-LSL-hMYCN-IRES-BFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm(CAG-LSL-HA-hMYCN-IRES-BFP-Wpre-polyA)1Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-225000
마우스
R26-CAG-LSL-hNFE2L2*G81S-IRES-Luc-2A-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-NFE2L2(G81S)-IRES-Luciferase-2A-tdTomato)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-190077
신청분야：cancer research
마우스
R26-CAG-LSL-hNRF2-IRES-Luc-2A-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-NRF2-IRES-luciferase-2A-tdTomato)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-18050
신청분야：Tumor research; drug screening
마우스
R26-CAG-LSL-hPIK3CA*H1047R-IRES-Luc-2A-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-PIK3CA(H1047R)-IRES-luciferase-2A-tdTomato)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-190065
Disease Connection：breast cancer, CLOVES syndrome, ovarian cancer, brain glioma
마우스
R26-CAG-LSL-hPLA2R1-IRES-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm(CAG-LSL-hPLA2R1-IRES-EGFP)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-220264
마우스
R26-CAG-LSL-hPLAG1-IRES-Luc-2A-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-hPLAG1-IRES-Luciferase-2A-tdTomato-wpre-polyA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-215002
마우스
R26-CAG-LSL-hPNPLA3-I148M-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-Frt-2xpolyA-CAG-Frt-LSL-hPNPLA3 I148M-IRES-GFP-wpre-polyA)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-200013
신청분야：rs738409：148 isoleucine to Methionine protein variant,I148M.Non-alcoholic fatty liver and hepatitis B cirrhosis research.
마우스
R26-CAG-LSL-hPROCR
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-FRT-2xpA-CAG-FRT-LSL-Kozak-hPROCR-WPRE-pA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-240013
마우스
R26-CAG-LSL-hREST-IRES-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-REST-IRES-tdTomato-WPRE-polyA)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-200051
신청분야：Cancer and aging research
위로 点击跳转到顶部