1. 홈페이지
  2. Models
  3. U-GEMMs
  4. Standard GEMMs
  5. Humanized Knockins

Models

Humanized Knockins

The humanized knockin mouse model is a general term that refers to a mouse that has been engrafted with a short strand of human DNA. These strains may be used to streamline drug development, assess PK/PD of novel therapeutics, model human disease and explore pathogenic mechanisms, and more.

마우스
R26-CAG-LSL-hTPM3-NTRK1-IRES-Luc-2A-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm(SA-polyA-CAG-LSL-TPM3-NTRK1-IRES-luc-2A-tdTomato-WPRE-polyA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-190098
신청분야：Colorectal carcinoma related.
마우스
R26-CAG-LSL-hTSHRa(BALB/c)
모델명：BALB/cJSmo-Gt(ROSA)26Sortm1(CAG-loxP-STOP-lox2272-hTSHRa-loxP-lox2272-WPRE-pA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-234654
마우스
R26-CAG-LSL-hWNT1
모델명：C57BL/6JSmo-Gt(ROSA)26Sorem1(SA-FRT-2xpA-CAG-FRT-loxp-STOP-loxp-WNT1-IRES-Luciferase-2A-tdTomato-WPRE-polyA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-190128
신청분야：Wnt1 signaling pathway, cancer research, etc
마우스
R26-CAG-LSL-SOX2-IRES-Luc-2A-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sorem(CAG-LSL-SOX2-IRES-Luciferase-2a-EGFP-WPRE-polyA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-210138
신청분야：Fluorescent reporter Mice
마우스
R26-hCD46-IRES-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-hCD46-IRES-tdTomato-polyA)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-190087
신청분야：Immune-related
마우스
R26-LSL-hEZH2-IRES-Luc-2A-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-EZH2-IRES-luciferase-2A-tdTomato)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-18053
신청분야：Tumor research; drug screening
마우스
R26-LSL-hIGF1R-IRES-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-Kozak-hIGF1R-IRES-EGFP-WPRE-pA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-231795
마우스
R26-LSL-hIL15-Flag-IRES-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm(CAG-Loxp-Stop-Loxp-Kozak-hIL2 signal peptide-hIL15-Flag-IRES-EGFP-polyA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-220130
마우스
R26-LSL-hNTN1
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-LSL-Kozak-hNTN1-WPRE-pA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-233967
마우스
R26-pAPOE-hCYP3A4(FVB)
모델명：FVB-Gt(ROSA)26Sortm1(pAPOE-CYP3A4)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-18032
신청분야：metabolism
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