1. 홈페이지
  2. Models
  3. U-GEMMs
  4. Standard GEMMs
  5. Humanized Knockins

Models

Humanized Knockins

The humanized knockin mouse model is a general term that refers to a mouse that has been engrafted with a short strand of human DNA. These strains may be used to streamline drug development, assess PK/PD of novel therapeutics, model human disease and explore pathogenic mechanisms, and more.

마우스
R26-CAG-LSL-hREST4-IRES-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-REST4-IRES-EGFP-WPRE-polyA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-200052
마우스
R26-CAG-LSL-hRHOA*Y42C-IRES-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-FRT-2xpolyA-CAG-FRT-LSL-RHOA(Y42C)-IRES-tdTomato-WPRE-polyA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-200048
신청분야：Cancer research
마우스
R26-CAG-LSL-hSIGLEC8-IRES-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-SIGLEC8-IRES-EGFP-WPRE-polyA)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-210137
신청분야：Fluorescent reporter Mice
마우스
R26-CAG-LSL-hSNCA*A53T-IRES-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-SNCA A53T-IRES-EGFP-WPRE-polyA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-200320
마우스
R26-CAG-LSL-hSOD1*G94A-IRES-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-FRT-LSL- SOD1(G94A)-IRES-EGFP-WPRE-pA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-200263
Disease Connection：amyotrophic lateral sclerosis type 1
마우스
R26-CAG-LSL-hSOS-F-tdTomato
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-FRT-2xpolyA-CAG-FRT-loxp-Stop-loxp-SOS-F-IRES-tdTomato-WPRE-PA)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-200020
신청분야：Spontaneous skin cancer model
마우스
R26-CAG-LSL-hSOX2-IRES-Luc-2A-EGFP/Kras-LSL-G12D
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm(CAG-LSL-SOX2-IRES-Luciferase-2a-EGFP-WPRE-polyA)Krasem4(LSL-G12D)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-234153
마우스
R26-CAG-LSL-hTARDBP*A315T-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-3xFlag-TARDBP(A315T)-IRES-GFP-WPRE-PA)Smoc
모델 상태：Sperm cryopreservation | 카탈로그：NM-KI-200019
신청분야：Amyotrophic lateral sclerosis(ALS) and frontotemporal lobar degeneration research
마우스
R26-CAG-LSL-hTERT-IRES-Luc-2A-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(CAG-LSL-V5-TERT-IRES-Luciferase-2A-EGFP-WPRE-pA)Smoc
모델 상태：Repository Live | 카탈로그：NM-KI-18035
신청분야：Telomerase
마우스
R26-CAG-LSL-hTM6SF2*E167K-EGFP
모델명：C57BL/6JSmo-Gt(ROSA)26Sortm1(SA-Frt-2xpolyA-CAG-Frt-LSL-TM6SF2-IRES-GFP-WPRE-PA)Smoc
모델 상태：Embryo cryopreservation | 카탈로그：NM-KI-200017
신청분야：Non-alcoholic fatty liver disease
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